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ESPERO

Chief Executive Officer

united states / Posted
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The Chief Executive Officer (CEO) is responsible for driving ESPERO’s vision, strategy, and execution. This leader will oversee product, commercial, operations, finance, and culture — enabling sustainable growth while maintaining strong alignment with regulatory and scientific rigor.

The CEO will partner closely with the Founder (Kimberly Tableman) to scale ESPERO from a high-impact early-stage company to a category-defining leader in protocol intelligence and clinical research AI.

Key Responsibilities:

  • Own and execute ESPERO’s multi-year growth strategy, including product, commercial, regulatory, and partnerships.
  • Translate the Founder’s vision into executable priorities and operational plans.
  • Identify market opportunities in protocol optimization, clinical AI, digital design, and ecosystem data alignment.
  • Develop and articulate ESPERO’s positioning as the leader in protocol intelligence.

Product and Technology Leadership

  • Partner with Product & Engineering to define the roadmap for:
  • Digital protocol authoring (ICH-M11 aligned)
  • Amendment intelligence and risk scoring
  • Insights as a Service (IAAS)
  • Study design complexity scoring
  • Operational dataset (BRAID, USDM, etc.) integrations
  • Ensure regulatory-aligned data practices and scientific rigor.
  • Evaluate emerging technologies (LLMs, structured data harmonization, predictive models) and integrate them responsibly.

Commercial Growth and Revenue Expansion

  • Build a scalable commercial engine including sales, marketing, customer success, and partner channels.
  • Drive enterprise sales into pharma, biotech, CROs, and IRB networks.
  • Develop pricing, packaging, and channel strategies to accelerate ARR.
  • Oversee execution of client implementations, renewals, and expansions.

Partnerships

  • Forge strategic partnerships with data providers, technology platforms (e.g., Medidata, Veeva), CROs, regulatory-aligned partners, and real-world data companies.
  • Expand ESPERO’s ecosystem footprint, including academic, regulatory, and industry collaborations.
  • Represent ESPERO with investors, boards, and external stakeholders.

Team Leadership + Operational Excellence

  • Build and lead a high-performing, mission-aligned leadership team.
  • Create operational processes for planning, forecasting, finance, and risk management.
  • Establish KPIs and dashboards for performance, product adoption, and revenue.
  • Foster an empowering, transparent culture centered on innovation, accountability, and resilience.

Fundraising

  • Oversee future fundraising (Seed+, Series A) including:
  • Pitch development
  • Investor pipelines
  • Diligence readiness
  • Manage capital allocation, runway optimization, and financial planning.
  • Maintain strong relationships with current investors and board members.

Qualifications

Required:

  • Proven executive leadership experience in a SaaS, AI, life-sciences, or clinical-tech company.
  • Deep understanding of clinical research processes, protocol development, or data standards (ICH-M11, CDISC, USDM).
  • Experience driving growth from early-stage to $5M–$20M ARR.
  • Strong product intuition with ability to partner with technical teams.
  • Track record of enterprise sales and partnership development.
  • Exceptional communication, executive presence, and change leadership.

Preferred:

  • Experience with regulatory bodies, IRBs, or data interoperability.
  • Background in AI/ML-enabled platforms.
  • Prior CEO, COO, GM, or SVP-level P&L ownership.
  • Comfortable in a fast-paced, founder-driven environment.
  • Passion for transforming the clinical research ecosystem.